IP Consultant

 

Tel: +1 (301) 982 0152

Email: Lambert@dobelawgroup.com

 

Lambert C. M. Ngoka, Ph.D. is an IP Consultant and has a wealth of research experience in the chemical, biotechnological, and pharmaceutical arts and in such diverse areas as analytical, inorganic and organic chemistry, mass spectrometry, proteomics, genomics, bioinformatics, genetic engineering, and molecular biology.  He has particular expertise in biomedical applications of mass spectrometry, and has extensive biomedical research experience in cyclic peptides, glycolipids and oligosaccharides.

 

Practice Areas

 

·       Patent Prosecution

·       IP Opinions

 

Technology Areas

 

·       Chemistry/Pharmaceutical Sciences – Analytical, inorganic chemistry, organic chemistry

·       Biotechnology – genetic engineering, molecular biology, genomics, proteomics, cancer, biochemistry

 

 

Education

 

·       Postdoctoral Research Associate, Washington University, St Louis, Missouri

·       Postdoctoral Fellow, Boston University School of Medicine, Boston Massachusetts

·       Postdoctoral Associate, Massachusetts Institute of Technology, Cambridge, Massachusetts

·       Ph.D. Analytical Chemistry, University of California, Davis, California

·       M.S. Graduate Study in Analytical Chemistry, University of Alberta, Canada

·       M.S. Industrial Chemistry, University of Ibadan, Nigeria

·       B.A. First Class Honors, Chemistry, University of Ibadan, Nigeria

 

 

Professional Affiliations

 

·       American Society for Mass Spectrometry

·       American Chemical Society

 

 

  Representative Publications

 

• Ngoka, Lambert C. M., Dramatic down-regulation of oxidoreductases in human hepatocellular carcinoma hepG2 cells: proteomics and gene ontology unveiling new frontiers in cancer enzymology. Proteome Science 2008, 6(1):29 (24 October 2008)

 

• Ngoka, Lambert C. M., Sample prep for proteomics of breast cancer: proteomics and gene ontology reveal dramatic differences in protein solubilization preferences of radioimmunoprecipitation assay and urea lysis buffers. Proteome Science 2008, 6(1):30 (24 October 2008)

 

• Gao, S., Zhang, Z.-P., Edinboro, L.E., Ngoka Lambert, C. and Karnes, H.T. The effect of alkyl amine additives on the sensitivity of detection for paclitaxel and docetaxel and analysis in plasma of paclitaxel by liquid chromatography-tandem mass spectrometry. Biomedical chromatography: BMC 20, 683-695 (2006)

 

• Ngoka, Lambert C. M., Alkali Metals and Cyclic Peptides, In: The Encyclopedia of Mass Spectrometry : Fundamentals of and Applications to Organic (and Organicmetallic) Compounds-US-ISBN:0080438466 (Hardcover book) Vol.4 Gross, Michael L. /Caprioli, Richard M. (EDT) /Nibbering, Nico (EDT) /Publisher: Elsevier Science Ltd /12, 593-600 (2005).

 

• Ngoka, Lambert C. M., Gross, Michael L.  Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo (D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo (D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions.    Journal of Mass Spectrometry 35 (2), 265-276 (2000) 

 

• Ngoka, Lambert C. M., Gross, Michael L.  Multistep collisionally activated decomposition in an ion trap for the determination of the amino-acid sequence and gas-phase ion chemistry of lithium-coordinated valinomycin.   International Journal of Mass Spectrometry, 194 (2/3), 247-259 (2000).

 

• Ngoka, Lambert C. M., Gross, Michael L.  Multistep tandem mass spectrometry for sequencing cyclic peptides in an ion-trap mass spectrometer. Journal of the American Society for Mass Spectrometry, 10(8), 732-746 (1999) 

 

• Ngoka, Lambert C. M., Gross, Michael L.  A nomenclature system for labeling cyclic peptide fragments. Journal of the American Society for Mass Spectrometry, 10(4), 360-363 (1999) 

 

• Ngoka, Lambert C. M., Gross, Michael L., Toogood, Peter L.  Sodium-directed selective cleavage of lactones: A method for structure determination of cyclodepsipeptides    International Journal of Mass Spectrometry, 182/183 289-298 (1999) 

 

• Ngoka, Lambert C. M., Gross, Michael L. Novel sodium binding properties of some cyclopentapeptide endothelin A selective receptor antagonists: electrospray and fast-atom-bombardment mass spectrometric studies. Biochemical and Biophysical Research Communications, 254 (3), 713-719 (1999) 

 

• Costello, Catherine E., Helin, Jari and Ngoka, Lambert C. M., Utilization of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for structural studies related to biology and disease. SPIE — Volume 2680. Ultrasensitive Biochemical Diagnostics, Gerald E. Cohn, Steven A. Soper, C. H. Winston Chen, Editors, pp. 406-414 (1996).

 

• Costello, Catherine E.; Perreault, Heléne; Ngoka, Lambert C., Mass spectrometric and tandem mass spectrometric approaches to the analysis of glycoconjugates. In Mass Spectrometry in the Biological Sciences, Burlingame, A. L.; Carr, S. A., Eds.; The Humana Press, Inc.: Clifton, NJ, pp 365-384 (1996).

 

• Ngoka, Lambert C., Gal, Jean Francois; Lebrilla, Carlito B.  Effects of Cations and Charge Types on the Metastable Decay Rates of Oligosaccharides.    Analytical Chemistry 66 (5), 692-698 (1994). 

 

• Ngoka, Lambert, Lebrilla, Carlito B.  “Slow” metastable decomposition of oligosaccharide cations produced in an external source Fourier transform mass spectrometer. Journal of the American Society for Mass Spectrometry, 4 (3), 210-215 (1993) 

 

• Carroll, James A.; Ngoka, Lambert; Beggs, Cindy G.; Lebrilla, Carlito B.  Liquid secondary ion mass spectrometry/Fourier transform mass spectrometry of oligosaccharide anions.    Analytical Chemistry, 65 (11), 1582-1587 (1993) 

 

• Carroll, James A.; Ngoka, Lambert; McCullough, Sesi; Gard, Eric; Jones, A. Daniel; Lebrilla, Carlito B.  Quadrupole Fourier transform mass spectrometry of oligosaccharides. Analytical Chemistry, 63 (21), 2526-2529 (1991)